HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroborane Hydrofluoride → ethyl 4-fluoro-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroborane Hydrofluoride | HCID 9855450 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | ethyl 4-amino-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate | HCID 66703696 | — |
| Solvent | Water | HCID 962 | — |
| Product | ethyl 4-fluoro-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate | HCID 66703633 | — |
Reaction Steps
Ethyl 4-amino-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate was allowed to react with sodium nitrite (NaNO2) and trifluoroborane-hydrogen fluoride complex (BF3.HF) in water at 10° C. for 10 minutes. By post-treating the reaction liquid, ethyl 4-fluoro-2-{[(1S,2S)-2-pyrrolidin-1-ylcyclohexyl]amino}benzoate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106190B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-ffce739e005243c882101ec59ef75aed |
| Source note | uspto-grants-2012_01 |