HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 425989Generated: October 29, 2026
2,2,2-Trifluoroethanol → HCID 57867984, compound
https://huagongshe.com/reaction/425989
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2,2,2-Trifluoroethanol | HCID 6409 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 57867997 | HCID 57867997 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57867984 | HCID 57867984 | — |
Reaction Steps
Sodium hydride was added at room temperature to a DMF solution of ethyl 6-chloro-2-[(cyclopropylmethyl)amino]nicotinate and 2,2,2-trifluoroethanol, followed by stirring at 80° C. for 20 hours. By post-treating the reaction liquid, ethyl 2-[(cyclopropylmethyl)amino]-6-(2,2,2-trifluoroethoxy)nicotinate was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08106190B2 |
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| Source dataset | uspto-grants-2012_01 |
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| ORD ID | ord-2aeeeed24b6d4cc7986752b369ca0468 |
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| Source note | uspto-grants-2012_01 |
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