2,2,2-Trifluoroethanol → HCID 57867984, compound

HRID 425989Notes

Reaction equation

HRID 425989 reaction equation
[H-].[Na+].Cl[C:4]1[CH:14]=[CH:13][C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([NH:15][CH2:16][CH:17]2[CH2:19][CH2:18]2)[N:5]=1.[F:20][C:21]([F:25])([F:24])[CH2:22][OH:23]>CN(C=O)C>[CH:17]1([CH2:16][NH:15][C:6]2[N:5]=[C:4]([O:23][CH2:22][C:21]([F:25])([F:24])[F:20])[CH:14]=[CH:13][C:7]=2[C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH2:19][CH2:18]1

Participants

5

Reactant 3

HCID 64092,2,2-TrifluoroethanolHCID 24758Sodium hydrideHCID 57867997HCID 57867997, compound

Product 1

HCID 57867984HCID 57867984, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Sodium hydride was added at room temperature to a DMF solution of ethyl 6-chloro-2-[(cyclopropylmethyl)amino]nicotinate and 2,2,2-trifluoroethanol, followed by stirring at 80° C. for 20 hours. By post-treating the reaction liquid, ethyl 2-[(cyclopropylmethyl)amino]-6-(2,2,2-trifluoroethoxy)nicotinate was obtained.

Workup

  1. additionBy post-treating
  2. customthe reaction liquid

Sources & evidence

ORD record
ord-2aeeeed24b6d4cc7986752b369ca0468
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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