HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-Pyrrolidin-1-ylmethyl-cyclohexylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | HCID 66703668 | HCID 66703668 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Pyrrolidin-1-ylmethyl-cyclohexylamine | HCID 3159681 | — |
Reaction Steps
1-(Pyrrolidin-1-ylcarbonyl)cyclohexanamine hydrochloride was added under ice-cooling to a THF solution of LAH, followed by heating under reflux for 3 hours. Sodium hydroxide aqueous solution and sodium sulfate were added to the reaction liquid, followed by filtering. By concentrating the filtrate under a reduced pressure, 1-(pyrrolidin-1-ylmethyl)cyclohexanamine was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106190B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-69fdbddebf1546d18f2b046ef4cbe93d |
| Source note | uspto-grants-2012_01 |