Sodium Hydroxide → 1-Pyrrolidin-1-ylmethyl-cyclohexylamine

HRID 425991Notes

Reaction equation

HRID 425991 reaction equation
Cl.[N:2]1([C:7]([C:9]2([NH2:15])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=O)[CH2:6][CH2:5][CH2:4][CH2:3]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+].S([O-])([O-])(=O)=O.[Na+].[Na+]>C1COCC1>[N:2]1([CH2:7][C:9]2([NH2:15])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14]2)[CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 24436Sodium SulfateHCID 21226445Aluminium lithium hydrideHCID 66703668HCID 66703668, compound

Product 1

HCID 31596811-Pyrrolidin-1-ylmethyl-cyclohexylamine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-(Pyrrolidin-1-ylcarbonyl)cyclohexanamine hydrochloride was added under ice-cooling to a THF solution of LAH, followed by heating under reflux for 3 hours. Sodium hydroxide aqueous solution and sodium sulfate were added to the reaction liquid, followed by filtering. By concentrating the filtrate under a reduced pressure, 1-(pyrrolidin-1-ylmethyl)cyclohexanamine was obtained.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 3 hours
  3. filtrationby filtering
  4. concentrationBy concentrating the filtrate under a reduced pressure

Sources & evidence

ORD record
ord-69fdbddebf1546d18f2b046ef4cbe93d
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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