HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorophenol → 4-tert-butyl-2-fluorophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorophenol | HCID 9707 | — |
| Reactant | tert-BUTYL CHLORIDE | HCID 10486 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-tert-butyl-2-fluorophenol | HCID 11062790 | — |
Reaction Steps
Aluminum chloride and tert-butyl chloride were added under ice-cooling to 2-fluorophenol and stirred at room temperature. By adding water to the reaction liquid, concentrating the organic layer under a reduced pressure and crystallizing from hexane, 4-tert-butyl-2-fluorophenol was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106190B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-5bd8c46fcc1a459bb54347dcb7faae36 |
| Source note | uspto-grants-2012_01 |