2-Fluorophenol → 4-tert-butyl-2-fluorophenol

HRID 425999Notes

Reaction equation

HRID 425999 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Cl)([CH3:8])([CH3:7])[CH3:6].[F:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[OH:17]>O>[C:5]([C:15]1[CH:14]=[CH:13][C:12]([OH:17])=[C:11]([F:10])[CH:16]=1)([CH3:8])([CH3:7])[CH3:6]

Participants

5

Reactant 3

HCID 97072-FluorophenolHCID 10486tert-BUTYL CHLORIDEHCID 6451240Aluminum(III) Chloride

Product 1

HCID 110627904-tert-butyl-2-fluorophenol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Aluminum chloride and tert-butyl chloride were added under ice-cooling to 2-fluorophenol and stirred at room temperature. By adding water to the reaction liquid, concentrating the organic layer under a reduced pressure and crystallizing from hexane, 4-tert-butyl-2-fluorophenol was obtained.

Workup

  1. customto the reaction liquid
  2. concentrationconcentrating the organic layer under a reduced pressure
  3. customcrystallizing from hexane

Sources & evidence

ORD record
ord-5bd8c46fcc1a459bb54347dcb7faae36
Source dataset
uspto-grants-2012_01
Patent number
US08106190B2

Reaction notes

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