HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-(2-(methoxycarbonyl)aminoethoxy)-3-(3-chlorophenyl)propyl(methyl)carbamate → Methyl 2-(1-(3-chlorophenyl)-3-(methylamino)propoxy)ethylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-(2-(methoxycarbonyl)aminoethoxy)-3-(3-chlorophenyl)propyl(methyl)carbamate | HCID 66704353 | — |
| Solvent | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| Product | Methyl 2-(1-(3-chlorophenyl)-3-(methylamino)propoxy)ethylcarbamate | HCID 59364348 | 199.9% |
Reaction Steps
tert-butyl 3-(2-(methoxycarbonyl)aminoethoxy)-3-(3-chlorophenyl)propyl(methyl)carbamate (100 mg) was dissolved in a solution of 20% (V/V) TFA/CH2Cl2 (8 mL). The reaction mixture was stirred at room temperature for 1 h, then concentrated in vacuo to afford methyl 2-(1-(3-chlorophenyl)-3-(methylamino)propoxy)ethylcarbamate (150 mg, 100%), was used for the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08106221B2 |
| Source dataset | uspto-grants-2012_01 |
| ORD ID | ord-c802ecc19df146c99a27a550260b1b1f |
| Source note | uspto-grants-2012_01 |