HRID4261

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14030127

未命名化合物

结构：CC(=O)CC(=O)OCC1=C(C(=O)[O-])N2C(=O)[C@@H](NC(=O)Cc3csc(N)n3)[C@H]2SC1.[Na+]

HCID131715451

未命名化合物

PRODUCTS

生成物

结构：CC(=O)CC(=O)OCC1=C(C(=O)OC(OC(=O)CC(C)C)C(C)C)N2C(=O)[C@@H](NC(=O)Cc3csc(N)n3)[C@H]2SC1

HCID131715450

未命名化合物

收率 41%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度: -5 °C

PROCEDURE

实验过程

In 30 ml of N,N-dimethylformamide is dissolved 4.76 g of sodium 7β-[2-(2-aminothiazol-4-yl)acetamido]-3-acetoacetoxymethyl-ceph-3-em-4-carboxylate and the solution is cooled to -5° C. With stirring, 5.0 g of 1-iodo-2-methylpropyl 3-methylbutyrate is added dropwise, followed by stirring for further 5 minutes. Thereafter, following the procedupe of Example 1, 2.5 g of the title compound is obtained.

WORKUP

后处理

stirringby stirring for further 5 minutes

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-14d0b639897e4843a7bf6d6a18bfd472
来源数据集: uspto-grants-1988_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04725592
来源说明: uspto-grants-1988_02

反应 SMILES

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([NH:10][C@@H:11]2[C:29](=[O:30])[N:13]3[C:14]([C:26]([O-:28])=[O:27])=[C:15]([CH2:18][O:19][C:20](=[O:25])[CH2:21][C:22]([CH3:24])=[O:23])[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1.[Na+].[CH3:32][CH:33]([CH3:43])[CH2:34][C:35]([O:37][CH:38](I)[CH:39]([CH3:41])[CH3:40])=[O:36]>CN(C)C=O>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([NH:10][C@@H:11]2[C:29](=[O:30])[N:13]3[C:14]([C:26]([O:28][CH:38]([O:37][C:35](=[O:36])[CH2:34][CH:33]([CH3:43])[CH3:32])[CH:39]([CH3:41])[CH3:40])=[O:27])=[C:15]([CH2:18][O:19][C:20](=[O:25])[CH2:21][C:22]([CH3:24])=[O:23])[CH2:16][S:17][C@H:12]23)=[O:9])[N:6]=1