Hydrochloric Acid → 6-(3-Chloro-5-methyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

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Reaction Steps

(3-Chloro-5-methyl-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone (49) (3.4 g, 10 mmol) was refluxed with concentrated HCl (35 ml) for 4 hr. After cooling to room temperature, the white precipitate was collected by filtration, washed with cold water and hexane, and dried in high vacuo to afford 3 g (97%) of a white solid. m.p. 254-255° C.; 1H NMR (200 MHz, CDCl3/CD3OD) δ: 1.17 (6H, d, J=6.9 Hz), 2.25-2.45 (4H, m), 7.50-7.71 (3H, m); HRMS (EI): Calc. 306.077120, Found 306.076851.

Provenance & Evidence