反应详情

(3-Chloro-5-methyl-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone (49) (3.4 g, 10 mmol) was refluxed with concentrated HCl (35 ml) for 4 hr. After cooling to room temperature, the white precipitate was collected by filtration, washed with cold water and hexane, and dried in high vacuo to afford 3 g (97%) of a white solid. m.p. 254-255° C.; 1H NMR (200 MHz, CDCl3/CD3OD) δ: 1.17 (6H, d, J=6.9 Hz), 2.25-2.45 (4H, m), 7.50-7.71 (3H, m); HRMS (EI): Calc. 306.077120, Found 306.076851.

1. filtrationthe white precipitate was collected by filtration
2. washwashed with cold water and hexane
3. customdried in high vacuo