(3,5-Dichloro-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone → 6-(3,5-Dichloro-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

HRID 426134Notes

Reaction equation

HRID 426134 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([C:11]2[C:16]([CH:17]([CH3:19])[CH3:18])=[C:15]([O:20]C)[N:14]=[C:13]([O:22]C)[N:12]=2)=[O:10])[CH:5]=[C:6]([Cl:8])[CH:7]=1>Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([Cl:8])[CH:7]=1)[C:9]([C:11]1[NH:12][C:13](=[O:22])[NH:14][C:15](=[O:20])[C:16]=1[CH:17]([CH3:19])[CH3:18])=[O:10]

Participants

3

Reactant 1

HCID 59184648(3,5-Dichloro-phenyl)-(5-isopropyl-2,6-dimethoxy-pyrimidin-4-yl)-methanone

Product 1

HCID 213032336-(3,5-Dichloro-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dioneYield 87.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Compound (60) (2.0 g, 5.6 mmol) was refluxed with conc. HCl (30 ml) for 3 hr. After cooling to room temperature, the white precipitate was collected by filtration, washed with cold water, and dried in high vacuo to afford 1.6 g (87%) of the title compound as a white solid. m.p. 252-253° C.; 1H NMR (200 MHz, CDCl3/CD3OD) δ 1.11 (6H, d, J=6.9 Hz), 2.33 (1H, m), 7.61-7.73 (3H, m); HRMS (EI) Calcd. 326.0225, Found 326.0240.

Workup

  1. filtrationthe white precipitate was collected by filtration
  2. washwashed with cold water
  3. customdried in high vacuo

Sources & evidence

ORD record
ord-ebbaaf84dc164411b4d03c10b2057de2
Source dataset
uspto-grants-2012_01
Patent number
US08106064B2

Reaction notes

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