Dimethylformamide → HCID 59184688, compound

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	Lithium iodide	HCID 66321	—
Reactant	2-[4-(Chloromethyl)-2-pyridinyl]-1H-isoindole-1,3(2H)-dione	HCID 59184699	—
Reactant	3-(5-Isopropyl-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yloxy)-5-methyl-benzonitrile	HCID 59686837	—
Product	HCID 59184688	HCID 59184688	41%

Reaction Steps

To a stirred solution of (73) (297 mg, 1 mmol), anhydrous powdered potassium carbonate (134 mg, 1 mmol), and lithium iodide (134 mg, 1 mmol) in DMF (5 ml) at room temperature, was added 2-(4-Chloromethyl-pyridin-2-yl)-isoindole-1,3-dione (272 mg, 1 mmol). After stirring for overnight, the mixture was evaporated in vacuo and the residue was purified by silica gel column chromatography (eluent, EA:hexanes (1:1); Rf˜0.2 fraction was collected.) to afford 205 mg (41%) of a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08106064B2
Source dataset	uspto-grants-2012_01
ORD ID	ord-9e795b1b0d964b97b2763652e81dec6d
Source note	uspto-grants-2012_01