反应详情

To a stirred solution of (73) (297 mg, 1 mmol), anhydrous powdered potassium carbonate (134 mg, 1 mmol), and lithium iodide (134 mg, 1 mmol) in DMF (5 ml) at room temperature, was added 2-(4-Chloromethyl-pyridin-2-yl)-isoindole-1,3-dione (272 mg, 1 mmol). After stirring for overnight, the mixture was evaporated in vacuo and the residue was purified by silica gel column chromatography (eluent, EA:hexanes (1:1); Rf˜0.2 fraction was collected.) to afford 205 mg (41%) of a white solid.

1. customthe mixture was evaporated in vacuo
2. customthe residue was purified by silica gel column chromatography (eluent, EA:hexanes (1:1); Rf˜0.2 fraction was collected.)