Acetyl chloride → N-[6-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetamide

HRID 42623Notes

Reaction equation

HRID 42623 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[N:6][C:7]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)=[C:8]([C:11]3[CH:16]=[CH:15][N:14]=[C:13]([S:17][CH3:18])[N:12]=3)[CH:9]=2)[NH:4][N:3]=1.[C:26](Cl)(=[O:28])[CH3:27]>>[F:25][C:22]1[CH:23]=[CH:24][C:19]([C:7]2[N:6]=[C:5]3[NH:4][N:3]=[C:2]([NH:1][C:26](=[O:28])[CH3:27])[C:10]3=[CH:9][C:8]=2[C:11]2[CH:16]=[CH:15][N:14]=[C:13]([S:17][CH3:18])[N:12]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 178503413HCID 178503413, compound

Product 1

HCID 68444211N-[6-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetamide

Procedure

Following a similar procedure to that described in example 245, but starting from 3-amino-6-(4-fluorophenyl)-5-(2-methylsulfanylpyrimidin-4-yl)pyrazolo[3,4-b]pyridine (obtained in example 180) and acetyl chloride, the title compound was obtained.

Sources & evidence

ORD record
ord-3c45a0333043499fb2de6436f2dd333b
Source dataset
uspto-grants-2013_09
Patent number
US08536194B2

Reaction notes

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