HRID426351

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734325

3-Cyanophenylboronic acid

C7H6BNO2

结构：COC(=O)C(CC(C)C)c1cc(OS(=O)(=O)C(F)(F)F)cc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1

HCID57754914

未命名化合物

2 次

PRODUCTS

生成物

结构：COC(=O)C(CC(C)C)c1cc(-c2cccc(C#N)c2)cc(-c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1

HCID59004768

未命名化合物

收率 48%

PROCEDURE

实验过程

The title compound was prepared in 48% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-3′,5′-bis-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Intermediate A) and 3-cyanophenylboronic acid under the conditions described in Example 26, step (d).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0c3494acb08544c5ba4d19f5fd641be6
来源数据集: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08106236B2
来源说明: uspto-grants-2012_01

反应 SMILES

[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:32])([F:31])[F:30])[CH:26]=[C:25]([C:33]([F:36])([F:35])[F:34])[CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[C:38]([C:40]1[CH:41]=[C:42](B(O)O)[CH:43]=[CH:44][CH:45]=1)#[N:39]>>[CH3:1][O:2][C:3](=[O:37])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[C:27]([C:29]([F:31])([F:32])[F:30])[CH:26]=[C:25]([C:33]([F:34])([F:36])[F:35])[CH:24]=2)[CH:12]=[C:13]([C:44]2[CH:43]=[CH:42][CH:41]=[C:40]([C:38]#[N:39])[CH:45]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]