3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile → HCID 59004817, compound

HRID 426353Notes

Reaction equation

HRID 426353 reaction equation
[CH3:1][O:2][C:3](=[O:33])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=2)[CH:12]=[C:13](OS(C(F)(F)F)(=O)=O)[CH:14]=1)[CH2:5][CH:6]([CH3:8])[CH3:7].[F:34][C:35]1[CH:36]=[C:37]([CH:40]=[C:41](B2OC(C)(C)C(C)(C)O2)[CH:42]=1)[C:38]#[N:39]>>[CH3:1][O:2][C:3](=[O:33])[CH:4]([C:9]1[CH:10]=[C:11]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:31])([F:32])[F:30])=[CH:25][CH:24]=2)[CH:12]=[C:13]([C:41]2[CH:40]=[C:37]([C:38]#[N:39])[CH:36]=[C:35]([F:34])[CH:42]=2)[CH:14]=1)[CH2:5][CH:6]([CH3:7])[CH3:8]

Participants

3

Reactant 2

HCID 467381943-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrileHCID 59004769HCID 59004769, compound

Product 1

HCID 59004817HCID 59004817, compoundYield 21%

Procedure

The title compound was prepared in 21% yield from 4-methyl-2-(5-trifluoromethanesulfonyloxy-4′-trifluoromethyl-biphenyl-3-yl)-pentanoic acid methyl ester (prepared in Example 26, step (f)) and 3-fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile under the conditions described in Example 26, step (d).

Sources & evidence

ORD record
ord-aa1e000b675b47ccb624c68030edf483
Source dataset
uspto-grants-2012_01
Patent number
US08106236B2

Reaction notes

Loading…