反应详情

6.4 gm of methyl 2-[4-(4-chlorophenoxy-methyl)-phenoxy]-propionate were dissolved in 60 ml of methanol, 6.0 gm of n-butylamine were added to the solution, and the mixture was heated in an autoclave for 4 hours at a pressure of 15-16 atmospheres gauge. After cooling, the solvent was distilled off in vacuo, and the residue was recrystallized from ethanol, yielding 2.8 gm (39% of theory) of the amide named in the heading, which had a melting point of 98° C.

1. temperaturethe mixture was heated in an autoclave for 4 hours at a pressure of 15-16 atmospheres gauge
2. temperatureAfter cooling
3. distillationthe solvent was distilled off in vacuo
4. customthe residue was recrystallized from ethanol