Butylamine → 2-[4-(4-Chlorophenoxy-methyl)-phenoxy]-propionic acid n-butylamide

関与物質

反応手順

6.4 gm of methyl 2-[4-(4-chlorophenoxy-methyl)-phenoxy]-propionate were dissolved in 60 ml of methanol, 6.0 gm of n-butylamine were added to the solution, and the mixture was heated in an autoclave for 4 hours at a pressure of 15-16 atmospheres gauge. After cooling, the solvent was distilled off in vacuo, and the residue was recrystallized from ethanol, yielding 2.8 gm (39% of theory) of the amide named in the heading, which had a melting point of 98° C.

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