2-Amino-4,6-dimethyl pyrimidine → HCID 20390820, compound

HRID 426446Notes

Reaction equation

HRID 426446 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[C:10]1([S:16]([N:19]=[C:20]=[S:21])(=[O:18])=[O:17])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(#N)C>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[N:7]=[C:2]([NH:1][C:20](=[S:21])[NH:19][S:16]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)(=[O:18])=[O:17])[N:3]=1

Participants

4

Reactant 2

HCID 130212-Amino-4,6-dimethyl pyrimidineHCID 12207092Benzenesulfonyl isothiocyanate

Product 1

HCID 20390820HCID 20390820, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a dry suspension of 12.4 g of 2-amino-4,-6-dimethypyrimidine in 60 ml of acetonitrile was added 19.9 g of benzenesulfonyl isothiocyanate. The heavy white precipitate which formed was removed by filtration and washed with anhydrous ethyl ether. It melted at 165°170°. The product was N-[(4,6-dimethylpyrimidin-2-yl)-aminothioxomethyl]benzenesulfonamide.

Workup

  1. customThe heavy white precipitate which formed
  2. customwas removed by filtration
  3. washwashed with anhydrous ethyl ether
  4. custommelted at 165°170°

Sources & evidence

ORD record
ord-896d31118cf042299d6807418655dfa4
Source dataset
uspto-grants-1979_10
Patent number
US04169719

Reaction notes

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