Dimethylformamide → HCID 23452135, compound

HRID 426476Notes

Reaction equation

HRID 426476 reaction equation
[C:1]1(=[O:11])[NH:5][C:4](=[O:6])[C:3]2=[CH:7][CH:8]=[CH:9][CH:10]=[C:2]12.[K].CN(C)[CH:15]=[O:16]>>[O:16]1[CH:15]=[CH:1][CH:2]=[C:10]1[CH2:9][CH2:8][CH2:7][CH2:3][N:5]1[C:1](=[O:11])[C:2]2[C:3](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4]1=[O:6]

Participants

3

Reactant 2

HCID 6228DimethylformamideHCID 24194345Phthalimide potassium salt

Product 1

HCID 23452135HCID 23452135, compound

Procedure

2[1-(4-bromobutyl)]furan (406 mg) and potassium phthalimide (370 mg) were stirred together at room temperature in dry dimethylformamide overnight. The solution was poured into ice-water and the resulting white solid filtered, dried and recrystallised from chloroform/petroleum ether (b.p. 60°-80°) to give 2-[4-(2-Furanyl)butyl]-1H-isoindole-1,3(2H)-dione as white microcrystals (430 mg) m.p. 61°-63°.

Workup

  1. filtrationthe resulting white solid filtered
  2. customdried
  3. customrecrystallised from chloroform/petroleum ether (b.p. 60°-80°)

Sources & evidence

ORD record
ord-3a11d5aa0a214a5ca7fbbc4fb29ac07c
Source dataset
uspto-grants-1979_10
Patent number
US04169855

Reaction notes

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