反应详情

To a stirred solution of 456 mg of 4-hydroxy-4-vinyl-1-iodo-trans-1-octene and 320 mg of imidazole in 1.0 m of dimethylformamide is added 0.23 ml of chlorotrimethylsilane during 3 minutes. The mixture is stirred at room temperature for 22 hours and partitioned with a mixture of cold hexane and water. The hexane layer is washed repeatedly with water and then brine, dried over magnesium sulfate, and concentrated to give an oil, pmr spectrum (CDCl3): 0.13 (s, trimethylsiloxy group) and 2.32 (d, =CHCH2).

1. custompartitioned with a mixture of cold hexane and water
2. washThe hexane layer is washed repeatedly with water
3. dry with materialbrine, dried over magnesium sulfate
4. concentrationconcentrated
5. customto give an oil, pmr spectrum (CDCl3)