反应详情

A solution of 1,2-epoxy-3-(1-naphthyloxy)propane (62.0 g) and the amine of formula NHR2R3, pyrrolidine (23.5 g), in methanol (250 ml) is heated at reflux for two hours. The reaction mixture is concentrated to dryness. The oily residue is crystallized from chloroform and diethyl ether by the addition of hexane to give the title compound, mp 68°-70° C.

1. temperatureat reflux for two hours
2. concentrationThe reaction mixture is concentrated to dryness
3. customThe oily residue is crystallized from chloroform and diethyl ether by the addition of hexane