Methylamine → HCID 136398815, compound

HRID 426664Notes

Reaction equation

HRID 426664 reaction equation
[C:1]([C:9]1[C:10](=[O:23])[N:11]([CH3:22])[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:13][C:14]=1[OH:15])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:24][NH2:25]>C(O)C>[CH3:24][N:25]=[C:1]([C:9]1[C:10](=[O:23])[N:11]([CH3:22])[C:12]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[CH:13][C:14]=1[OH:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6329Methylamine2×HCID 13557405765767-13-7

Product 1

HCID 136398815HCID 136398815, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Three grams (0.0098 mole) of 3-benzoyl-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone is added to 30 milliliters of ethanol saturated with methylamine. The mixture is refluxed for two hours with a stream of methylamine passing through. The mixture is cooled and the resulting solid filtered and washed with ethanol and then ether to give 3-(α-N-methyliminobenzyl)-4-hydroxy-6-phenyl-1-methyl-2(1H)-pyridone; m.p. 225°-227° C.

Workup

  1. temperatureThe mixture is cooled
  2. filtrationthe resulting solid filtered
  3. washwashed with ethanol

Sources & evidence

ORD record
ord-eebe38e2596c43639db293693ec7b24f
Source dataset
uspto-grants-1979_10
Patent number
US04170705

Reaction notes

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