Bromobenzene → HCID 178486565, compound

HRID 426711Notes

Reaction equation

HRID 426711 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[C:9]([O:11][CH3:12])[C:8]([O:13][CH3:14])=[CH:7][C:6]=1[NH:15][C:16]([N:18]1CCCC1)=[O:17])(=N)=[O:3].BrC1C=CC=CC=1>>[CH3:14][O:13][C:8]1[C:9]([O:11][CH3:12])=[CH:10][C:5]2[SH:2](=[O:3])([CH3:1])[NH:18][C:16](=[O:17])[NH:15][C:6]=2[CH:7]=1

Participants

3

Reactant 2

HCID 7961BromobenzeneHCID 12694259HCID 12694259, compound

Product 1

HCID 178486565HCID 178486565, compound

Procedure

A solution was prepared from 42.8 g. of S-methyl-S-[2-(pyrrolidinylcarbonylamino)-4,5-dimethoxyphenyl]sulfoximine and 1 l. of bromobenzene. The reaction mixture was heated to reflux temperature for three hours, and was then cooled and filtered. The filter cake was dissolved in 700 ml. of chloroform. The chloroform solution was cooled and 6,7-dimethoxy-1-methyl-1H-1,2,4-benzothiadiazine-3(4H)-one-1-oxide formed in the above reaction crystallized therefrom. The crystalline material melted at 326°-328° C. (91 percent yield).

Workup

  1. customA solution was prepared from 42.8 g
  2. temperatureThe reaction mixture was heated
  3. temperatureto reflux temperature for three hours
  4. temperaturewas then cooled
  5. filtrationfiltered
  6. dissolutionThe filter cake was dissolved in 700 ml
  7. temperatureThe chloroform solution was cooled

Sources & evidence

ORD record
ord-348b9967b2f2460484c532439bf992fb
Source dataset
uspto-grants-1979_10
Patent number
US04171361

Reaction notes

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