2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline → HCID 21184055, compound

HRID 426717Notes

Reaction equation

HRID 426717 reaction equation
[CH2:1]([O:3][C:4]([NH:6][C:7]1[S:11][N:10]=[N:9][C:8]=1[C:12]([Cl:14])=[O:13])=[O:5])[CH3:2].[NH2:15][C:16]1[C:25]2[C:20](=[CH:21][C:22]([O:28][CH3:29])=[C:23]([O:26][CH3:27])[CH:24]=2)[N:19]=[C:18]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[N:17]=1>O1CCOCC1>[ClH:14].[NH2:15][C:16]1[C:25]2[C:20](=[CH:21][C:22]([O:28][CH3:29])=[C:23]([O:26][CH3:27])[CH:24]=2)[N:19]=[C:18]([N:30]2[CH2:35][CH2:34][N:33]([C:12]([C:8]3[N:9]=[N:10][S:11][C:7]=3[NH:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])=[O:13])[CH2:32][CH2:31]2)[N:17]=1

Participants

4

Reactant 2

HCID 6162672-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazolineHCID 21183974HCID 21183974, compound

Product 1

HCID 21184055HCID 21184055, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of 5-ethoxycarbonylamino-1,2,3-thiadiazole-4-carbonyl chloride (5.17 g., 0.022 mole) in dioxane (35 ml. was added to a solution of 4-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline (6.35 g., 0.022 mole) in dioxane (190 ml.). The resultant mixture was stirred at reflux for 1 hour, and then at 23° C. for 18 hours. Filtration gave the title compound; m.p. 281°-284° C. (dec.) after crystallization from methanol.

Workup

  1. temperatureat reflux for 1 hour
  2. filtrationFiltration

Sources & evidence

ORD record
ord-bc291755d62943d0af7ca4b2c0e9c3b9
Source dataset
uspto-grants-1979_10
Patent number
US04171363

Reaction notes

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