Ammonia → HCID 18621177, compound

HRID 426842Notes

Reaction equation

HRID 426842 reaction equation
C([N:4]1[C:12]2[C:7](=[C:8]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)[CH:9]=[CH:10][CH:11]=2)[CH:6]=[N:5]1)(=O)C.N.C(=O)=O.O>C(Cl)Cl>[O:17]1[CH2:16][CH:15]1[CH2:14][O:13][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[CH:6]=[N:5][NH:4]2

Participants

6

Reactant 4

HCID 222AmmoniaHCID 280Carbon DioxideHCID 962WaterHCID 197882791-{4-[(Oxiran-2-yl)methoxy]-1H-indazol-1-yl}ethan-1-one

Product 1

HCID 18621177HCID 18621177, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1-Acetyl-4-(2,3-epoxypropoxy)-indazole is stirred for 4 hours in a mixture of methylene chloride and liquid ammonia, using a solid carbon dioxide cooler. The reaction mixture is then evaporated in a vacuum to give a brownish oil which is pure enough for further reactions. By stirring with water, there is obtained a beige product which melts at about 60° C. (after melting, it again solidifies and then melts again at <260° C.).

Workup

  1. customThe reaction mixture is then evaporated in a vacuum
  2. customto give a brownish oil which
  3. customthere is obtained a beige product which melts at about 60° C. (
  4. custommelts again at <260° C.

Sources & evidence

ORD record
ord-562c39fdf9204c1781df4da9990de757
Source dataset
uspto-grants-1979_10
Patent number
US04171446

Reaction notes

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