HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 18621177, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Carbon Dioxide | HCID 280 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 1-{4-[(Oxiran-2-yl)methoxy]-1H-indazol-1-yl}ethan-1-one | HCID 19788279 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 18621177 | HCID 18621177 | — |
Reaction Steps
1-Acetyl-4-(2,3-epoxypropoxy)-indazole is stirred for 4 hours in a mixture of methylene chloride and liquid ammonia, using a solid carbon dioxide cooler. The reaction mixture is then evaporated in a vacuum to give a brownish oil which is pure enough for further reactions. By stirring with water, there is obtained a beige product which melts at about 60° C. (after melting, it again solidifies and then melts again at <260° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04171446 |
| Source dataset | uspto-grants-1979_10 |
| ORD ID | ord-562c39fdf9204c1781df4da9990de757 |
| Source note | uspto-grants-1979_10 |