Sodium Hydroxide → HCID 20390079, compound

HRID 426883Notes

Reaction equation

HRID 426883 reaction equation
[CH3:1][S:2][CH2:3][S:4][CH:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]([O:8]CSC)=[O:7].[OH-].[Na+]>C(O)C>[CH3:1][S:2][CH2:3][S:4][CH:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:6]([OH:8])=[O:7]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86734401HCID 86734401, compound

Product 1

HCID 20390079HCID 20390079, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.9 gms. of DL-α-[[(methylthio)methyl]thio]benzene acetic acid, (methylthio)methyl ester are dissolved in 10 ml. of ethanol. 20 ml. of 1 N alcoholic sodium hydroxide solution are added and the mixture is permitted to stand overnight. This is then concentrated, the residue is dissolved in water, the aqueous solution is extracted once with ether, then acidificed and the oil is extracted with ether. After drying with magnesium sulfate and evaporating the solvent 1.8 gms. of DL-α-[[(methylthio)methyl]thio]benzeneacetic acid are obtained as an oil.

Workup

  1. concentrationThis is then concentrated
  2. dissolutionthe residue is dissolved in water
  3. extractionthe aqueous solution is extracted once with ether
  4. extractionthe oil is extracted with ether
  5. dry with materialAfter drying with magnesium sulfate
  6. customevaporating the solvent 1.8 gms

Sources & evidence

ORD record
ord-4c0050867aa14ece9576a0c6f81eaeab
Source dataset
uspto-grants-1979_10
Patent number
US04171435

Reaction notes

Loading…