Hydrochloric Acid → 3,5-Dichlorobenzoic acid

HRID 426926ノート

反応式

HRID 426926 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[C:4]([C:5]([OH:7])=[O:6])[C:3]=1N.C(O)C.Cl.N([O-])=O.[Na+]>O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:11])[CH:10]=1)[C:5]([OH:7])=[O:6]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 760363,5-Dichloroanthranilic acidHCID 23668193Sodium Nitrite

生成物 1

HCID 58113,5-Dichlorobenzoic acid収率 89%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
75 °C

実験手順

206 parts of 3,5-dichloroanthranilic acid are introduced into 400 parts of ethanol and 400 parts of 36 percent strength by weight hydrochloric acid are then added. A solution of 100 parts of NaNO2 in 150 parts of water is run in at 75° C., resulting in the evolution of nitrogen. The mixture is stirred for one hour at 75° C. and is then cooled, 1,500 parts of water are added and the product is filtered off. 183 parts (89% of theory) of 3,5-dichlorobenzoic acid of melting point 170°-175° C. are obtained.

後処理

  1. additionare then added
  2. customis run in at 75° C.
  3. customresulting in the evolution of nitrogen
  4. temperatureis then cooled
  5. filtrationthe product is filtered off

出典と根拠

ORDレコード
ord-46a69279afa746b1840cf31972658799
出典データセット
uspto-grants-1979_10
特許番号
US04172098

反応ノート

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