Methylamine → HCID 54157643, compound

HRID 426939Notes

Reaction equation

HRID 426939 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([CH:7]=[CH:8][C:9](Cl)=[O:10])[C:4]([N+:12]([O-:14])=[O:13])=[N:3]1.[CH3:15][NH2:16]>C1(C)C=CC=CC=1>[CH3:15][NH:16][C:9](=[O:10])[CH:8]=[CH:7][C:5]1[C:4]([N+:12]([O-:14])=[O:13])=[N:3][N:2]([CH3:1])[CH:6]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 54231082HCID 54231082, compound

Product 1

HCID 54157643HCID 54157643, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

0.54 g. 3-(1-methyl-3-nitro-4-pyrazolyl)-acrylic acid chloride (preparation see Example 2) is dissolved in 20 ml. anhydrous toluene and, while stirring at 25° C., methylamine gas is passed in for about 10 minutes. The precipitated crystals are filtered off with suction, washed with toluene, triturated with water and dried in a vacuum. There is thus obtained 0.43 g. 3-(1-methyl-3-nitro-4-pyrazolyl)-acrylic acid N-methylamide; m.p. 200°-203° C.

Workup

  1. customis passed in for about 10 minutes
  2. filtrationThe precipitated crystals are filtered off with suction
  3. washwashed with toluene
  4. customtriturated with water
  5. customdried in a vacuum

Sources & evidence

ORD record
ord-0cd06f3de26344ebb42f7e783102ebdf
Source dataset
uspto-grants-1979_10
Patent number
US04172136

Reaction notes

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