9-(2-Cyclohexenyl)-2-ethoxy-9H-adenine → 2-n-Hexyloxy-9-cyclohexyl-9H-adenine

HRID 427013Notes

Reaction equation

HRID 427013 reaction equation
C1(N2C=NC3C2=NC(OCC)=NC=3N)CCCC=C1.[CH:20]1([N:26]2[CH:34]=[N:33][C:32]3[C:27]2=[N:28][C:29]([O:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42])=[N:30][C:31]=3[NH2:35])[CH2:25][CH2:24][CH2:23][CH:22]=[CH:21]1>>[CH2:37]([O:36][C:29]1[N:28]=[C:27]2[C:32]([N:33]=[CH:34][N:26]2[CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[C:31]([NH2:35])[N:30]=1)[CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]

Participants

3

Reactant 2

HCID 127778299-(2-Cyclohexenyl)-2-ethoxy-9H-adenineHCID 127778359-(2-cyclohexenyl)-2-n-hexyloxy-9H-adenine

Product 1

HCID 127778452-n-Hexyloxy-9-cyclohexyl-9H-adenineYield 90%

Procedure

The procedure of Example 8 was repeated except that the 9-(2-cyclohexenyl)-2-ethoxy-9H-adenine used therein was replaced by an equivalent weight of 9-(2-cyclohexenyl)-2-n-hexyloxy-9H-adenine. There was produced the title product in 90% yield; m.p. 57°-60° C. IR(neat): 3500, 1635, 1595, 1500, 1465, 1420, 1400 cm-1. UV: λmaxEtOH 253 nm(ε 7200), 270 nm(ε 10900). NMR(CDCl3): 1.5(21H, m), 4.25(2H, t, J=6.5 Hz), 4.40(1H, m), 6.07(2H, s), 7.54(1H, s).

Sources & evidence

ORD record
ord-283a9d06677c42c99ecef0f5b50241ea
Source dataset
uspto-grants-1979_10
Patent number
US04172829

Reaction notes

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