反应详情

A mixture of 45 mg of 3-fluoromethyl-7β-phenylacetylamino-ceph-3-em-4-carboxylic acid tert.-butyl ester and 2 ml of trifluoroacetic acid is left to stand for 30 minutes at room temperatur. The trifluoroacetic acid is then removed under reduced pressure and the residue is washed with acetone/ethyl ether mixture to give 3-fluoromethyl-7β-phenylacetylamino-ceph-3-em-4-carboxylic acid as an amorphous powder; thin layer chromatogram on silica gel (system: chloroform/methanol 1:1): Rf~0.50; ultraviolet absorption spectrum (ethanol): λmax : 259μ (ε=5300); infrared absorption spectrum (nujol): characteristic bands at 3.02μ; 5.60μ; 5.78μ; 6.06μ and 6.51μ.

1. waitis left
2. customThe trifluoroacetic acid is then removed under reduced pressure
3. washthe residue is washed with acetone/ethyl ether mixture