反应详情

A mixture of 16 g. (88 mmole) of 3,4-dimethyloxyphenylethylamine and 13.5 g. (88 mmole) of p-methoxystyrene oxide is heated with stirring under argon on a steam bath overnight. A sample is withdrawn from the reaction mixture and chromatographed on a silica column, eluting with benzene ethyl acetate to isolate the pure product in crystalline form. To the remainder of the reaction mixture is added 100 ml. of ethyl acetate-hexane (1:1) and seeded with the crystalline product, with stirring and chilling. Filtration furnishes the product N-[2-(3,4-dimethoxyphenyl)-ethyl]-2-hydroxy-2-(4-methoxyphenyl)ethylamine, m.p. 92° C.

1. additionA mixture of 16 g
2. customA sample is withdrawn from the reaction mixture
3. customchromatographed on a silica column
4. washeluting with benzene ethyl acetate
5. customto isolate the pure product in crystalline form
6. additionTo the remainder of the reaction mixture is added 100 ml
7. stirringwith stirring
8. temperaturechilling
9. filtrationFiltration