HRID427102

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID12733746

4-(Morpholin-4-yl)butanoic acid--hydrogen chloride (1/1)

C8H16ClNO3

结构：CC(CCCc1ccc(F)cc1)c1cc(O)c2c(c1)OC(C)(C)C1=C2CN(CC(=O)NC(N)=O)CC1

HCID44327286

未命名化合物

PRODUCTS

生成物

结构：CC(CCCc1ccc(F)cc1)c1cc(OC(=O)CCCN2CCOCC2)c2c(c1)OC(C)(C)C1=C2CN(CC(=O)NC(N)=O)CC1.Cl

HCID70607348

未命名化合物

PROCEDURE

实验过程

The above-titled compound was prepared according to the method of Example 8 by reacting equimolar quantities of {{8-[5-(4-fluorophenyl)-2-pentyl]-10-hydroxy-5,5-dimethyl-1,2,3,4-tetrahydro-5H-[1]benzopyrano[4,3-c]pyridin-2-yl}acetyl}urea and 4-morpholinobutyric acid hydrochloride in the presence of dicyclohexylcarbodiimide.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d0d7f9618e934b80a7c42fc6237fd214
来源数据集: uspto-grants-1979_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04172943
来源说明: uspto-grants-1979_10

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([C:13]2[CH:18]=[C:17]([OH:19])[C:16]3[C:20]4[CH2:21][N:22]([CH2:30][C:31]([NH:33][C:34]([NH2:36])=[O:35])=[O:32])[CH2:23][CH2:24][C:25]=4[C:26]([CH3:29])([CH3:28])[O:27][C:15]=3[CH:14]=2)[CH3:12])=[CH:4][CH:3]=1.[ClH:37].[O:38]1[CH2:43][CH2:42][N:41]([CH2:44][CH2:45][CH2:46][C:47](O)=[O:48])[CH2:40][CH2:39]1.C1(N=C=NC2CCCCC2)CCCCC1>>[ClH:37].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH:11]([C:13]2[CH:18]=[C:17]([O:19][C:47](=[O:48])[CH2:46][CH2:45][CH2:44][N:41]3[CH2:40][CH2:39][O:38][CH2:43][CH2:42]3)[C:16]3[C:20]4[CH2:21][N:22]([CH2:30][C:31]([NH:33][C:34]([NH2:36])=[O:35])=[O:32])[CH2:23][CH2:24][C:25]=4[C:26]([CH3:29])([CH3:28])[O:27][C:15]=3[CH:14]=2)[CH3:12])=[CH:4][CH:3]=1