Diazomethane → HCID 20388125, compound

HRID 427128Notes

Reaction equation

HRID 427128 reaction equation
[CH3:1][O:2][C:3]1[C:8]2[C:9](=[O:18])[C:10]3[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=3[CH2:12][CH2:13][C:7]=2[CH:6]=[C:5]([C:19]([OH:21])=[O:20])[CH:4]=1.[N+](=[CH2:24])=[N-]>CN(C)C=O>[CH3:1][O:2][C:3]1[C:8]2[C:9](=[O:18])[C:10]3[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=3[CH2:12][CH2:13][C:7]=2[CH:6]=[C:5]([C:19]([O:21][CH3:24])=[O:20])[CH:4]=1

Participants

4

Reactant 2

HCID 9550DiazomethaneHCID 20388071HCID 20388071, compound

Product 1

HCID 20388125HCID 20388125, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

4-Methoxy-10,11-dihydro-5-oxo-5H-dibenzo[a.d]cycloheptene-2-carboxylic acid (4.0 g) is dissolved in dimethylformamide (30 ml) and to the solution is added excess ethereal diazomethane. The mixture is evaporated to low volume, poured into water and extracted with ethyl acetate. The extract is washed, dried and evaporated to yield methyl 4-methoxy-10,11-dihydro-5-oxo-5H-dibenzo[a,d]cycloheptene-2-carboxylate. 1.0 G of this compound is refluxed for 1 hour in carbon tetrachloride (50 ml) containing N-bromosuccinimide (0.635 g) while irradiating the mixture with a 100 watt incandescent lamp. The solution is cooled, filtered and evaporated. The residue is dissolved in dimethylformamide (10 ml) and 1,5-diazabicyclo[4.3.0]non-5-ene (1.0 ml) is added. The mixture is heated to 70° for 30 minutes then cooled and poured into water. The solution is extracted with ethyl acetate, and the extract washed, dried and evaporated to afford methyl 4-methoxy-5-oxo-5H-dibenzo[a,d]cycloheptene-2-carboxylate. This material is refluxed for 3 hours in water (10 ml) and methanol (2.5 ml) containing sodium hydroxide (0.5 g). The cooled solution is acidified with 2 N hydrochloric acid and extracted with ethyl acetate. The extract is dried and evaporated. The residue is recrystallized from aqueous methanol to afford 4-methoxy-5-oxo-5H-dibenzo[a,d]cycloheptene-2-carboxylic acid, mp 252°-253°.

Workup

  1. customThe mixture is evaporated to low volume
  2. additionpoured into water
  3. extractionextracted with ethyl acetate
  4. washThe extract is washed
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-9f203c1007274fdebc87ca9655bef017
Source dataset
uspto-grants-1979_10
Patent number
US04172949

Reaction notes

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