反应详情

A solution of 3,4-dichloroaniline (200 g., 1.23 mole), cycloheptene oxide (400 ml.), and concentrated HCl (2 ml.) is heated at reflux temperature for seven (7) days. The unreacted epoxide is evaporated at 60° C. and the residue is treated with excess ethereal HCl, and a syrup results. This is washed with 1000 ml. ether. The residue is crystallized and recrystallized from methanol/ether (1/5,5, v/v ) to give trans-3,4-dichloro-N-(2-hydroxycycloheptyl)aniline, hydrochloride salt.

1. customThe unreacted epoxide is evaporated at 60° C.
2. additionthe residue is treated with excess ethereal HCl
3. customa syrup results
4. washThis is washed with 1000 ml
5. customThe residue is crystallized
6. customrecrystallized from methanol/ether (1/5,5