Hydrochloric Acid → HCID 12361857, compound

HRID 427163Notes

Reaction equation

HRID 427163 reaction equation
Cl.[C:2]([CH2:7][N:8]1[C:20]2[CH2:19][CH2:18][CH:17]([N:21]([CH3:23])[CH3:22])[CH2:16][C:15]=2[C:14]2[C:9]1=[CH:10][CH:11]=[CH:12][CH:13]=2)([O:4]CC)=[O:3].Cl>>[CH3:22][N:21]([CH3:23])[CH:17]1[CH2:16][C:15]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:8]([CH2:7][C:2]([OH:4])=[O:3])[C:20]=2[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12361856HCID 12361856, compound

Product 1

HCID 12361857HCID 12361857, compound

Procedure

A mixture of 9.9 g. of 9-carbethoxymethyl-3-(dimethylamino)-1,2,3,4-tetrahydrocarbazole hydrochloride (Example 14) in 50 ml. of 6-N hydrochloric acid was heated on a steam bath for one and one-half hours, cooled, and the resulting solids were collected by filtration to give, after recrystallization from ethyl alcohol-water, 6.26 g. of 3-(dimethylamino)-9-carboxymethyl-1,2,3,4-tetrahydrocarbazole hydrochloride, m.p. 316°-319° C.

Workup

  1. additionA mixture of 9.9 g
  2. temperaturecooled
  3. filtrationthe resulting solids were collected by filtration
  4. customto give
  5. customafter recrystallization from ethyl alcohol-water, 6.26 g

Sources & evidence

ORD record
ord-769a18d4245c4d5cbef6b107f1c86d94
Source dataset
uspto-grants-1979_10
Patent number
US04172834

Reaction notes

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