HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 22274990, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Amino-4,6-dichloropyrimidine | HCID 79434 | — |
| Reactant | Neopentylamine | HCID 79882 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 22274990 | HCID 22274990 | — |
Reaction Steps
A solution of 5-amino-4,6-dichloropyrimidine (1 mmol) in nBuOH was treated with Et3N (1.2 mmol) and neopentylamine (1.05 mmol) at 80° C. After 12 h, the cooled reaction mixture was evaporated under vacuum and the residue was chromatographed to give 6-chloro-5-amino-4-(neopentylamino)-pyrimidine as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06312662B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-e357a22d484a42378a8d91356332edf1 |
| Source note | uspto-grants-2001_11 |