Triethylamine → HCID 22274990, compound

HRID 427219Notes

Reaction equation

HRID 427219 reaction equation
[NH2:1][C:2]1[C:3]([Cl:9])=[N:4][CH:5]=[N:6][C:7]=1Cl.CCN(CC)CC.[CH2:17]([NH2:22])[C:18]([CH3:21])([CH3:20])[CH3:19]>C(O)CCC>[Cl:9][C:3]1[N:4]=[CH:5][N:6]=[C:7]([NH:22][CH2:17][C:18]([CH3:21])([CH3:20])[CH3:19])[C:2]=1[NH2:1]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 794345-Amino-4,6-dichloropyrimidineHCID 79882Neopentylamine

Product 1

HCID 22274990HCID 22274990, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of 5-amino-4,6-dichloropyrimidine (1 mmol) in nBuOH was treated with Et3N (1.2 mmol) and neopentylamine (1.05 mmol) at 80° C. After 12 h, the cooled reaction mixture was evaporated under vacuum and the residue was chromatographed to give 6-chloro-5-amino-4-(neopentylamino)-pyrimidine as a yellow solid.

Workup

  1. customthe cooled reaction mixture
  2. customwas evaporated under vacuum
  3. customthe residue was chromatographed

Sources & evidence

ORD record
ord-e357a22d484a42378a8d91356332edf1
Source dataset
uspto-grants-2001_11
Patent number
US06312662B1

Reaction notes

Loading…