Aluminium lithium hydride → N9-cyclohexylethyl-8-hydroxymethyladenine

HRID 427220Notes

Reaction equation

HRID 427220 reaction equation
[CH:1]1([CH2:7][CH2:8][N:9]2[C:17]([C:18](OC)=[O:19])=[N:16][C:15]3[C:10]2=[N:11][CH:12]=[N:13][C:14]=3[NH2:22])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH:1]1([CH2:7][CH2:8][N:9]2[C:17]([CH2:18][OH:19])=[N:16][C:15]3[C:10]2=[N:11][CH:12]=[N:13][C:14]=3[NH2:22])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 54390366N9-cyclohexylethyl-8-methoxycarbonyladenine

Product 1

HCID 53681681N9-cyclohexylethyl-8-hydroxymethyladenine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of N9-cyclohexylethyl-8-methoxycarbonyladenine (1 mmol) in tetrahydrofuran was treated with lithium aluminum hydride (1 mmol) at 0° C. for 1 h. Extraction and chromatography give N9-cyclohexylethyl-8-hydroxymethyladenine as a white solid.

Workup

  1. extractionExtraction and chromatography

Sources & evidence

ORD record
ord-89668010d9ef44ce81f56189cdbffc07
Source dataset
uspto-grants-2001_11
Patent number
US06312662B1

Reaction notes

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