HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Trifluoromethyl)phenol → HCID 18356788, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Trifluoromethyl)phenol | HCID 7376 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Methyl-2-(methylsulfonyl)-6-[4-(trifluoromethyl)phenyl]pyrimidine | HCID 18356784 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 18356788 | HCID 18356788 | 96.8% |
Reaction Steps
0.32 g of the compound from example 2 are stirred with 0.18 g 3-trifluoromethylphenol and 0.25 g potassium carbonate in 25 ml dry acetonitrile at reflux for 4 hrs. The mixture is diluted with water and extracted with ethyl acetate. 0.39 g of the title compound were isolated (m.p. 124-127° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313072B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-e6da855d1dcc401ea24ad3864ceb1d11 |
| Source note | uspto-grants-2001_11 |