3-(Trifluoromethyl)phenol → HCID 18356788, compound

HRID 427238Notes

Reaction equation

HRID 427238 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[C:4](S(C)(=O)=O)[N:3]=1.[F:22][C:23]([F:32])([F:31])[C:24]1[CH:25]=[C:26]([OH:30])[CH:27]=[CH:28][CH:29]=1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C.O>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:5]=[C:4]([O:30][C:26]2[CH:27]=[CH:28][CH:29]=[C:24]([C:23]([F:22])([F:31])[F:32])[CH:25]=2)[N:3]=1

Participants

6

Reactant 3

HCID 73763-(Trifluoromethyl)phenolHCID 11430Potassium CarbonateHCID 183567844-Methyl-2-(methylsulfonyl)-6-[4-(trifluoromethyl)phenyl]pyrimidine

Product 1

HCID 18356788HCID 18356788, compoundYield 96.8%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Procedure

0.32 g of the compound from example 2 are stirred with 0.18 g 3-trifluoromethylphenol and 0.25 g potassium carbonate in 25 ml dry acetonitrile at reflux for 4 hrs. The mixture is diluted with water and extracted with ethyl acetate. 0.39 g of the title compound were isolated (m.p. 124-127° C.).

Workup

  1. temperatureat reflux for 4 hrs
  2. extractionextracted with ethyl acetate

Sources & evidence

ORD record
ord-e6da855d1dcc401ea24ad3864ceb1d11
Source dataset
uspto-grants-2001_11
Patent number
US06313072B1

Reaction notes

Loading…