反应详情

To a solution of 2-nitro-5-chloro-phenol (2.2 g, 14.0 mmol) in ethanol (40 mL) was added PtS2-C (5%, 200 mg) and hydrogenated at 45 psi for 4 hours. The mixture was filtered through celite and washed with ethyl acetate (100 mL). The solvent was evaporated and purified by chromatography ((ethyl acetate-hexanes: 2-3) to afford 1.89 g (95%) of a light brown solid. Recrystallization afforded an analytical sample: mp 149-151° C.

1. filtrationThe mixture was filtered through celite
2. washwashed with ethyl acetate (100 mL)
3. customThe solvent was evaporated
4. custompurified by chromatography ((ethyl acetate-hexanes: 2-3)