HCID 13608622, compound → HCID 131722952, compound

HRID 427266Notes

Reaction equation

HRID 427266 reaction equation
[CH2:1]([N:8]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[O:11][C:10](=[CH:18][NH:19][C:20](=[O:33])[CH2:21][CH:22]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[NH:26][CH:25]=2)C)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C2C(=CC=CC=2)C=C1CCCC(O)=O>>[CH2:1]([N:8]1[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2[O:11][C:10](=[CH:18][NH:19][C:20](=[O:33])[CH2:21][CH2:22][C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[NH:26][CH:25]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 13608622HCID 13608622, compoundHCID 131722953HCID 131722953, compound

Product 1

HCID 131722952HCID 131722952, compoundYield 63%

Procedure

N-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-ylylmethyl)-3-(1H-indol-3-yl)-butyramide. (4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methylamnine (1.2 g, 4.7 mmol) was coupled to indole butyric acid (1.8 g, 8.9 mmol) according to the procedure used to prepare intermediatel 1 above to afford 1.3 g (63%) of the title compound as a yellow solid: mp 61-63.5° C.; MS (EI) m/e 439 (M+)

Workup

  1. customto prepare intermediatel 1 above

Sources & evidence

ORD record
ord-6014c4b7c2b34a8498017ec794ec3e70
Source dataset
uspto-grants-2001_11
Patent number
US06313114B1

Reaction notes

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