HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-Methoxy-2-(trifluoromethyl)benzo[d]thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-Methoxy-2-aminobenzothiazole | HCID 21622 | — |
| Solvent | 1,2-Dichlorobenzene | HCID 7239 | — |
| Product | 4-Methoxy-2-(trifluoromethyl)benzo[d]thiazole | HCID 18357001 | — |
Reaction Steps
Starting from 2-amino-4-methoxybenzothiazole (1.5 g) and trifluoroacetic acid (5.5 ml), without 1,2 dichlorobenzene. Purification by flash chromatography (eluent 20% ethyl acetate/hexane) yielded the title compound as a light brown oil (0.74 g). TLC Rf 0.70 (50% ethyl acetate in hexane)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313116B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-56ce66e72e984e86a4c202acdde71ffd |
| Source note | uspto-grants-2001_11 |