Trifluoroacetic acid → 4-Methoxy-2-(trifluoromethyl)benzo[d]thiazole

HRID 427285Notes

Reaction equation

HRID 427285 reaction equation
N[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1.[F:13][C:14]([F:19])([F:18])C(O)=O>ClC1C=CC=CC=1Cl>[CH3:12][O:11][C:7]1[C:5]2[N:6]=[C:2]([C:14]([F:19])([F:18])[F:13])[S:3][C:4]=2[CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 216224-Methoxy-2-aminobenzothiazole

Product 1

HCID 183570014-Methoxy-2-(trifluoromethyl)benzo[d]thiazole

Reagents, catalysts & solvents 1

HCID 72391,2-DichlorobenzeneSolvent

Procedure

Starting from 2-amino-4-methoxybenzothiazole (1.5 g) and trifluoroacetic acid (5.5 ml), without 1,2 dichlorobenzene. Purification by flash chromatography (eluent 20% ethyl acetate/hexane) yielded the title compound as a light brown oil (0.74 g). TLC Rf 0.70 (50% ethyl acetate in hexane)

Workup

  1. customPurification by flash chromatography (eluent 20% ethyl acetate/hexane)

Sources & evidence

ORD record
ord-56ce66e72e984e86a4c202acdde71ffd
Source dataset
uspto-grants-2001_11
Patent number
US06313116B1

Reaction notes

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