N-Bromosuccinamide → 354760-28-4

HRID 427287Notes

Reaction equation

HRID 427287 reaction equation
[Br:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1.[Br:13]NC(=O)CCC(N)=O>C(#N)C>[Br:1][C:2]1[S:3][C:4]2[C:10]([Br:13])=[CH:9][CH:8]=[C:7]([O:11][CH3:12])[C:5]=2[N:6]=1

Participants

4

Reactant 2

HCID 9834204N-BromosuccinamideHCID 183569972-Bromo-4-methoxy-1,3-benzothiazole

Product 1

HCID 18356994354760-28-4Yield 119.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Starting from 2-bromo-4-methoxybenzothiazole (1.6 g), N-bromosuccinamide (0.91 g) and acetonitrile (100 ml). Purification by flash chromatography (eluent 20% ethylacetate/hexane) yielded the title compound as an off-white solid (1.8 g). TLC Rf 0.31 (20% ethyl acetate in heptane).

Workup

  1. customPurification by flash chromatography (eluent 20% ethylacetate/hexane)

Sources & evidence

ORD record
ord-950237d0a2f64321b1fcd2e90aa0eea7
Source dataset
uspto-grants-2001_11
Patent number
US06313116B1

Reaction notes

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