HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Nitrophenol → 2-Cyclopropyl-4-methoxybenzothiazole-7-carboxylic acid 4-nitrophenyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Nitrophenol | HCID 980 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2-Cyclopropyl-4-methoxybenzothiazole-7-carboxylic acid | HCID 18357008 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Cyclopropyl-4-methoxybenzothiazole-7-carboxylic acid 4-nitrophenyl ester | HCID 69690690 | 72.3% |
Reaction Steps
Starting from 2-cyclopropyl-4-methoxybenzothiazole-7-carboxylic acid (270 mg), p-nitrophenol (165 mg), and 1-(3-dimethylaminopropyl)-3-ethyl carbodiimide hydrochloride (228 mg) in dichloromethane (35 ml). Trituration ofthe residue with diethyl ether yielded the title compound as a bright yellow solid (290 mg). TLC Rf 0.60 (ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06313116B1 |
| Source dataset | uspto-grants-2001_11 |
| ORD ID | ord-702aba683958496691c97b925030b450 |
| Source note | uspto-grants-2001_11 |