反应详情

1,4-Dichlorophthalazine (20.0 g, 0.100 mol) was added to a boiling solution of hydrazine monohydrate (37.3 ml, 0.765 mol) in ethanol (500 ml) and the mixture heated at reflux for 0.5 h. The mixture was cooled to room temperature and the solid collected by filtration. The material was washed with ether, azeotroped with ethanol and dried in vacuo to afford the title-compound. 1H NMR (250 MHz, d6-DMSO) δ 7.72-8.35 (4H, m, 4 of Ar—H).

1. temperaturethe mixture heated
2. temperatureat reflux for 0.5 h
3. filtrationthe solid collected by filtration
4. washThe material was washed with ether
5. customazeotroped with ethanol
6. customdried in vacuo
7. customto afford the title-compound